› 2e6i

Solution NMR

Solution structure of the BTK motif of tyrosine-protein kinase ITK from human

Released:
DOI: 10.2210/pdb2e6i/pdb
PDB entry 2e6i coloured by chain, ensemble of 20 models, front view.
PDB entry 2e6i coloured by chain, ensemble of 20 models, side view.
PDB entry 2e6i coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Li H, Tochio N, Koshiba S, Watanabe S, Harada T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q08881 (Residues: 113-169; Coverage: 9%)
Gene names: EMT, ITK, LYK
Sequence domains: BTK motif
Structure domains: btk motif of tyrosine-protein kinase itk

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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