› 2eav

X-ray diffraction
2.2Å resolution

Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ibeta

Released:
DOI: 10.2210/pdb2eav/pdb
PDB entry 2eav coloured by chain, front view.
PDB entry 2eav coloured by chain, side view.
PDB entry 2eav coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.
Cho S, Wang Q, Swaminathan CP, Hesek D, Lee M, Boons GJ, Mobashery S, Mariuzza RA
Proc Natl Acad Sci U S A 104 8761-6 (2007)
PMID: 17502600

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidoglycan recognition protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 17.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96LB8 (Residues: 209-373; Coverage: 46%)
Gene names: PGLYRP4, PGRPIB, SBBI67
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

1 bound ligand:
Ligand NI 6 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 127.435Å b: 56.785Å c: 36.761Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.229 0.285
Expression system: Escherichia coli BL21(DE3)

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Citations

13 review citations

Bacterial cell-wall recycling.
Johnson et al. (2013)
12 more

1 mention without citation

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.
Cho et al. (2007)