› 2ejm

Solution NMR

Solution structure of RUH-072, an apo-biotnyl domain form human acetyl coenzyme A carboxylase

Released:
DOI: 10.2210/pdb2ejm/pdb
PDB entry 2ejm coloured by chain, ensemble of 20 models, front view.
PDB entry 2ejm coloured by chain, ensemble of 20 models, side view.
PDB entry 2ejm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ruhul Momen AZM, Hirota H, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RQ3 (Residues: 640-725; Coverage: 12%)
Gene names: MCCA, MCCC1
Sequence domains: Biotin-requiring enzyme
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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