› 2ela

X-ray diffraction
2Å resolution

Crystal Structure of the PTB domain of human APPL1

Released:
DOI: 10.2210/pdb2ela/pdb
PDB entry 2ela coloured by chain, front view.
PDB entry 2ela coloured by chain, side view.
PDB entry 2ela coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the BAR-PH and PTB domains of human APPL1.
Li J, Mao X, Dong LQ, Liu F, Tong L
Structure 15 525-33 (2007)
PMID: 17502098

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193846 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DCC-interacting protein 13-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UKG1 (Residues: 493-646; Coverage: 22%)
Gene names: APPL, APPL1, DIP13A, KIAA1428
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A, NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 45.533Å b: 61.593Å c: 60.745Å
α: 90° β: 101.22° γ: 90°
R-values:
R R work R free
0.222 0.222 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Mechanisms shaping the membranes of cellular organelles.
Shibata et al. (2009)
10 more

4 mentions without citation

Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.
Liu et al. (2013)
3 more