2erm

Solution NMR

Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Fibroblast growth factor 1 Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 17-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: IDS, GNS, IDR, NGY
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing, restrained molecular dynamics
Expression system: Escherichia coli BL21(DE3)