› 2etm

X-ray diffraction
2.3Å resolution

Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative

Released:
DOI: 10.2210/pdb2etm/pdb
PDB entry 2etm coloured by chain, front view.
PDB entry 2etm coloured by chain, side view.
PDB entry 2etm coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Lee CC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 281 amino acids
Theoretical weight: 32.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05397 (Residues: 411-689; Coverage: 27%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 7PY 2 x 7PY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P1
Unit cell:
a: 45.7Å b: 51.919Å c: 66.884Å
α: 100.08° β: 103.94° γ: 90.17°
R-values:
R R work R free
0.215 0.21 0.295
Expression system: Spodoptera frugiperda

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