› 2f7k

X-ray diffraction
2.8Å resolution

Crystal Structure of Human Pyridoxal Kinase

Released:
DOI: 10.2210/pdb2f7k/pdb
PDB entry 2f7k coloured by chain, front view.
PDB entry 2f7k coloured by chain, side view.
PDB entry 2f7k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human pyridoxal kinase.
Cao P, Gong Y, Tang L, Leung YC, Jiang T
J Struct Biol 154 327-32 (2006)
PMID: 16600635

Function and Biology Details

Reaction catalysed: 
ATP + pyridoxal = ADP + pyridoxal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyridoxal kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 37.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00764 (Residues: 1-312; Coverage: 100%)
Gene names: C21orf124, C21orf97, PDXK, PKH, PNK, PRED79
Sequence domains: Phosphomethylpyrimidine kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43
Unit cell:
a: 52.5Å b: 52.5Å c: 301Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.228 0.271
Expression system: Escherichia coli

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Citations

2 review citations

Vitamin B6: a long known compound of surprising complexity.
Mooney et al. (2009)
1 more