› 2fau

X-ray diffraction
2.1Å resolution

Crystal structure of human vps26

Released:
DOI: 10.2210/pdb2fau/pdb
PDB entry 2fau coloured by chain, front view.
PDB entry 2fau coloured by chain, side view.
PDB entry 2fau coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain.
Shi H, Rojas R, Bonifacino JS, Hurley JH
Nat Struct Mol Biol 13 540-8 (2006)
PMID: 16732284

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130958 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vacuolar protein sorting-associated protein 26A Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 40.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75436 (Residues: 1-327; Coverage: 100%)
Gene names: VPS26, VPS26A
Sequence domains: Vacuolar protein sorting-associated protein 26
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand CAF 2 x CAF

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID, null
Spacegroup: P212121
Unit cell:
a: 40.964Å b: 76.368Å c: 126.491Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.235 0.284
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Retrograde transport from endosomes to the trans-Golgi network.
Bonifacino et al. (2006)
35 more

12 mentions without citation

Retromer.
Bonifacino et al. (2008)
11 more