› 2fbu

Solution NMR

Solution structure of the N-terminal fragment of human LL-37

Released:
DOI: 10.2210/pdb2fbu/pdb
PDB entry 2fbu coloured by chain, ensemble of 5 models, front view.
PDB entry 2fbu coloured by chain, ensemble of 5 models, side view.
PDB entry 2fbu coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.
Li X, Li Y, Han H, Miller DW, Wang G
J Am Chem Soc 128 5776-85 (2006)
PMID: 16637646

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide LL-23 Chain: H
Molecule details ›
Chain: H
Length: 12 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49913 (Residues: 134-145; Coverage: 9%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: LPS binding domain of CAP18 (C terminal)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

32 review citations

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense.
Lai et al. (2009)
31 more

1 mention without citation

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments.
Wang et al. (2014)