PDB 2fd6 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

Biochemical function:

metal ion binding

Biological process:

immune response

Cellular component:

extracellular space

Sequence domains:

7 more domains

Structure domains:

Structure analysis Details

Assembly composition:

hetero tetramer (preferred)

Assembly name:

uPA-uPAR complex (preferred)

PDBe Complex ID:

PDB-CPX-133294 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (6 distinct):

Urokinase-type plasminogen activator long chain A Chain: A

Molecule details ›

Chain: A
Length: 122 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:

Canonical: P00749 (Residues: 31-152; Coverage: 30%)

Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:

Ig-like domain-containing protein Chain: L

Molecule details ›

Chain: L
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
UniProt:

Canonical: Q52L64 (Residues: 21-239; Coverage: 96%)

Gene names: Gm10883, Igkv8-30
Sequence domains:

Structure domains: Immunoglobulins

Ig-like domain-containing protein Chain: H

Molecule details ›

Chain: H
Length: 213 amino acids
Theoretical weight: 22.98 KDa
Source organism: Mus musculus
UniProt:

Canonical: Q924Q0 (Residues: 2-142; Coverage: 99%)

Gene name: V165-D-J-C mu
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Urokinase plasminogen activator surface receptor Chain: U

Molecule details ›

Chain: U
Length: 276 amino acids
Theoretical weight: 30.67 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt: