› 2fei

Solution NMR

Solution structure of the second SH3 domain of Human CMS protein

Released:
DOI: 10.2210/pdb2fei/pdb
PDB entry 2fei coloured by chain, ensemble of 20 models, front view.
PDB entry 2fei coloured by chain, ensemble of 20 models, side view.
PDB entry 2fei coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl.
Yao B, Zhang J, Dai H, Sun J, Jiao Y, Tang Y, Wu J, Shi Y
Biochim Biophys Acta 1774 35-43 (2007)
PMID: 17188587

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD2-associated protein Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 7.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y5K6 (Residues: 111-166; Coverage: 9%)
Gene name: CD2AP
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing molecular dynamics torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

SH3 domains: modules of protein-protein interactions.
Kurochkina et al. (2013)
1 more

2 mentions without citation

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Rouka et al. (2015)
1 more