› 2fho

Solution NMR

NMR solution structure of the human spliceosomal protein complex p14-SF3b155

Released:
DOI: 10.2210/pdb2fho/pdb
PDB entry 2fho coloured by chain, ensemble of 20 models, front view.
PDB entry 2fho coloured by chain, ensemble of 20 models, side view.
PDB entry 2fho coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Kuwasako K, Dohmae N, Inoue M, Shirouzu M, Guntert P, Seraphin B, Muto Y, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131049 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Splicing factor 3B subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75533 (Residues: 379-424; Coverage: 4%)
Gene names: SAP155, SF3B1
Sequence domains: Splicing factor 3B subunit 1
Splicing factor 3B subunit 6 Chain: B
Molecule details ›
Chain: B
Length: 87 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3B4 (Residues: 8-93; Coverage: 69%)
Gene names: CGI-110, HSPC175, HT006, SAP14, SF3B14, SF3B14A, SF3B6
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, RESTRAINTED ENERGY MINIMIZATION
Expression system: Escherichia coli

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