› 2fix

X-ray diffraction
3.5Å resolution

Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitiors

Released:
DOI: 10.2210/pdb2fix/pdb
PDB entry 2fix coloured by chain, front view.
PDB entry 2fix coloured by chain, side view.
PDB entry 2fix coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.
Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW
Bioorg Med Chem Lett 16 1807-10 (2006)
PMID: 16446092

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase 1 Chains: A, D, H, L
Molecule details ›
Chains: A, D, H, L
Length: 338 amino acids
Theoretical weight: 36.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 1-338; Coverage: 100%)
Gene names: FBP, FBP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 870 4 x 870
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P212121
Unit cell:
a: 84.4Å b: 108.672Å c: 196.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.307 0.252 0.355
Expression system: Escherichia coli

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Citations

1 review citation

Recent and emerging anti-diabetes targets.
Mohler et al. (2009)
23 other articles

2 mentions without citation

Analysis of nodule senescence in pea (Pisum sativum L.) using laser microdissection, real-time PCR, and ACC immunolocalization.
Serova et al. (2017)
1 more