› 2fj9

X-ray diffraction
1.6Å resolution

High resolution crystal structure of the unliganded human ACBP

Released:
DOI: 10.2210/pdb2fj9/pdb
PDB entry 2fj9 coloured by chain, front view.
PDB entry 2fj9 coloured by chain, side view.
PDB entry 2fj9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand.
Taskinen JP, van Aalten DM, Knudsen J, Wierenga RK
Proteins 66 229-38 (2007)
PMID: 17044054

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-CoA-binding protein Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07108 (Residues: 2-87; Coverage: 99%)
Gene name: DBI
Sequence domains: Acyl CoA binding protein
Structure domains: Acyl-CoA Binding Protein

Ligands and Environments

3 bound ligands:
Ligand PB 1 x PB
Ligand ZN 1 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P6522
Unit cell:
a: 43.824Å b: 43.824Å c: 177.247Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.229
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins.
Neess et al. (2015)
5 more

5 mentions without citation

Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
Fan et al. (2010)
4 more