› 2fjl

Solution NMR

Solution Structure of the Split PH domain in Phospholipase C-gamma1

Released:
DOI: 10.2210/pdb2fjl/pdb
PDB entry 2fjl coloured by chain, ensemble of 15 models, front view.
PDB entry 2fjl coloured by chain, ensemble of 15 models, side view.
PDB entry 2fjl coloured by chain, ensemble of 15 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.
Wen W, Yan J, Zhang M
J Biol Chem 281 12060-8 (2006)
PMID: 16500902

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145418 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.92 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P10686 (Residues: 851-933; Coverage: 6%)
Gene name: Plcg1
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Multiple roles of phosphoinositide-specific phospholipase C isozymes.
Suh et al. (2008)
9 more

4 mentions without citation

Structural and functional integration of the PLCĪ³ interaction domains critical for regulatory mechanisms and signaling deregulation.
Bunney et al. (2012)
3 more