Function and Biology Details
Reactions catalysed:
GTP + H(2)O = GDP + phosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphoinositide phospholipase C family
- C2 domain
- Small GTPase
- C2 domain superfamily
- Phospholipase C, phosphatidylinositol-specific, Y domain
- Phosphatidylinositol-specific phospholipase C, X domain
- PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
- PLC-beta, PH domain
7 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158899 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related C3 botulinum toxin substrate 1
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 178 amino acids
Theoretical weight: 19.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P63000 (Residues: 1-177; Coverage: 92%)
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Molecule details ›
Chain: B
Length: 799 amino acids
Theoretical weight: 91.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 799 amino acids
Theoretical weight: 91.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q00722 (Residues: 1-803; Coverage: 67%)
Sequence domains:
- PH domain
- Phosphoinositide-specific phospholipase C, efhand-like
- Phosphatidylinositol-specific phospholipase C, X domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- C2 domain
