› 2fl5

X-ray diffraction
3Å resolution

Cofactor-containing antibodies: Crystal structure of the original yellow antibody

Released:
DOI: 10.2210/pdb2fl5/pdb
PDB entry 2fl5 coloured by chain, front view.
PDB entry 2fl5 coloured by chain, side view.
PDB entry 2fl5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cofactor-containing antibodies: crystal structure of the original yellow antibody.
Zhu X, Wentworth P, Kyle RA, Lerner RA, Wilson IA
Proc Natl Acad Sci U S A 103 3581-5 (2006)
PMID: 16537445

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212312 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, C, E, L
Molecule details ›
Chains: A, C, E, L
Length: 209 amino acids
Theoretical weight: 22.42 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5FWF9 (Residues: 20-112, 113-229; Coverage: 98%)
Gene name: IGL@
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin Igg1 Heavy chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 220 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand RBF 4 x RBF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 100.592Å b: 111.105Å c: 188.454Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.24 0.29

Quick links

Citations

5 review citations

Heterogeneity of monoclonal antibodies.
Liu et al. (2008)
4 more

6 mentions without citation

The association of heavy and light chain variable domains in antibodies: implications for antigen specificity.
Chailyan et al. (2011)
5 more