Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Coagulation factor VIIa - tissue factor complex (preferred)
PDBe Complex ID:
PDB-CPX-140352 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Factor VII light chain
Molecule details ›
Chain: L
Length: 152 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 152 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P08709 (Residues: 61-212; Coverage: 34%)
Sequence domains:
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- EGF-like domain
- Coagulation Factor Xa inhibitory site
Factor VII heavy chain
Molecule details ›
Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P08709 (Residues: 213-466; Coverage: 57%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Tissue factor
Molecule details ›
Chain: T
Length: 218 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 218 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P13726 (Residues: 34-251; Coverage: 83%)
Sequence domains:
Structure domains: Immunoglobulins
