› 2fly

Solution NMR

Proadrenomedullin N-Terminal 20 Peptide

Released:
DOI: 10.2210/pdb2fly/pdb
PDB entry 2fly coloured by chain, ensemble of 20 models, front view.
PDB entry 2fly coloured by chain, ensemble of 20 models, side view.
PDB entry 2fly coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth.
Lucyk S, Taha H, Yamamoto H, Miskolzie M, Kotovych G
Biopolymers 81 295-308 (2006)
PMID: 16315141

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152886 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proadrenomedullin N-20 terminal peptide Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35318 (Residues: 22-41; Coverage: 12%)
Gene names: ADM, AM

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance Geometry Simulated Annealing Torsion Angle Dynamics

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Citations

3 review citations

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
2 more

2 mentions without citation

Membrane catalysis of peptide-receptor binding.
Langelaan et al. (2010)
1 more