› 2fr3

X-ray diffraction
1.48Å resolution

Crystal Structure of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinoic Acid at 1.48 Angstroms Resolution

Released:
DOI: 10.2210/pdb2fr3/pdb
PDB entry 2fr3 coloured by chain, front view.
PDB entry 2fr3 coloured by chain, side view.
PDB entry 2fr3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.
Vaezeslami S, Mathes E, Vasileiou C, Borhan B, Geiger JH
J Mol Biol 363 687-701 (2006)
PMID: 16979656

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular retinoic acid-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29373 (Residues: 2-138; Coverage: 99%)
Gene name: CRABP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand REA 1 x REA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID, null
Spacegroup: P212121
Unit cell:
a: 44.287Å b: 46.464Å c: 77.261Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.126 0.174
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Yabut et al. (2023)
11 other articles

8 mentions without citation

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal.
Martín-Gago et al. (2019)
7 more