› 2fry

Solution NMR

Solution structure of the third SH3 domain of human NCK2 adaptor protein

Released:
DOI: 10.2210/pdb2fry/pdb
PDB entry 2fry coloured by chain, ensemble of 10 models, front view.
PDB entry 2fry coloured by chain, ensemble of 10 models, side view.
PDB entry 2fry coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins.
Liu J, Li M, Ran X, Fan JS, Song J
Biochemistry 45 7171-84 (2006)
PMID: 16752908

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic protein NCK2 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O43639 (Residues: 198-256; Coverage: 16%)
Gene names: GRB4, NCK2
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Receptors for myelin inhibitors: Structures and therapeutic opportunities.
Cao et al. (2010)
4 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)