› 2fvz

X-ray diffraction
2.4Å resolution

Human Inositol Monophosphosphatase 2

Released:
DOI: 10.2210/pdb2fvz/pdb
PDB entry 2fvz coloured by chain, front view.
PDB entry 2fvz coloured by chain, side view.
PDB entry 2fvz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ogg D, Hallberg BM, Arrowsmith C, Berglund H, Collins R, Edwards A, Ehn M, Flodin S, Graslund S, Hammarstrom M, Hogbom M, Holmberg-Schiavone L, Kotenyova T, Kursula P, Nilsson-Ehle P, Nordlund P, Nyman T, Persson C, Sagemark J, Stenmark P, Sundstrom M, Van Den Berg S, Weigelt J, Thorsell AG, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 273 amino acids
Theoretical weight: 29.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14732 (Residues: 16-288; Coverage: 95%)
Gene names: IMP.18P, IMPA2
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-5
Spacegroup: P21
Unit cell:
a: 65.03Å b: 96.95Å c: 106.97Å
α: 90° β: 90.03° γ: 90°
R-values:
R R work R free
0.214 0.211 0.297
Expression system: Escherichia coli BL21(DE3)

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