› 2fxf

X-ray diffraction
2Å resolution

Human spermidine/spermine N1-acetyltransferase

Released:
DOI: 10.2210/pdb2fxf/pdb
PDB entry 2fxf coloured by chain, front view.
PDB entry 2fxf coloured by chain, side view.
PDB entry 2fxf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min JR, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diamine acetyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21673 (Residues: 2-171; Coverage: 99%)
Gene names: SAT, SAT1
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand ACO 2 x ACO
2 bound ligands:
Ligand CA 5 x CA
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 65.631Å b: 66.738Å c: 95.66Å
α: 90° β: 94.41° γ: 90°
R-values:
R R work R free
0.196 0.194 0.25
Expression system: Escherichia coli

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