› 2fyj

Solution NMR

NMR Solution structure of calcium-loaded LRP double module

Released:
DOI: 10.2210/pdb2fyj/pdb
PDB entry 2fyj coloured by chain, ensemble of 15 models, front view.
PDB entry 2fyj coloured by chain, ensemble of 15 models, side view.
PDB entry 2fyj coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.
Jensen GA, Andersen OM, Bonvin AM, Bjerrum-Bohr I, Etzerodt M, Thøgersen HC, O'Shea C, Poulsen FM, Kragelund BB
J Mol Biol 362 700-16 (2006)
PMID: 16938309

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor-related protein 1 515 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 8.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07954 (Residues: 932-1013; Coverage: 2%)
Gene names: A2MR, APR, LRP1
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMMULATED ANNEALING USING XPLOR-NIH, REFINEMENT IN EXPLICIT WATER LAYER USING CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
4 more

1 mention without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)