› 2g3r

X-ray diffraction
1.25Å resolution

Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution

Released:
DOI: 10.2210/pdb2g3r/pdb
PDB entry 2g3r coloured by chain, front view.
PDB entry 2g3r coloured by chain, side view.
PDB entry 2g3r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G
Cell 127 1361-73 (2006)
PMID: 17190600

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TP53-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12888 (Residues: 1484-1603; Coverage: 6%)
Gene name: TP53BP1
Sequence domains: Tumour suppressor p53-binding protein-1 Tudor
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2
Unit cell:
a: 55.895Å b: 77.834Å c: 36.35Å
α: 90° β: 121.13° γ: 90°
R-values:
R R work R free
0.196 0.194 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

252 review citations

Chromatin modifications and their function.
Kouzarides T. (2007)
251 more

12 mentions without citation

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Botuyan et al. (2006)
11 more