› 2g7i

X-ray diffraction
1.75Å resolution

Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for Atypical Hemolytic Uremic Syndrome

Released:
DOI: 10.2210/pdb2g7i/pdb
PDB entry 2g7i coloured by chain, front view.
PDB entry 2g7i coloured by chain, side view.
PDB entry 2g7i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, Goldman A
EMBO J 25 1784-94 (2006)
PMID: 16601698

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1107-1231; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: I4122
Unit cell:
a: 91.41Å b: 91.41Å c: 110.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.225
Expression system: Komagataella pastoris

Quick links

Citations

25 review citations

Atypical hemolytic-uremic syndrome.
Noris et al. (2009)
24 more

19 mentions without citation

Structural basis for engagement by complement factor H of C3b on a self surface.
Morgan et al. (2011)
18 more