› 2gf2

X-ray diffraction
2.38Å resolution

Crystal structure of human hydroxyisobutyrate dehydrogenase

Released:
DOI: 10.2210/pdb2gf2/pdb
PDB entry 2gf2 coloured by chain, front view.
PDB entry 2gf2 coloured by chain, side view.
PDB entry 2gf2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Papagrigoriou E, Salah E, Turnbull AP, Smee C, Burgess N, Gileadi O, von Delft F, Gorrec F, Arrowsmith CH, Weigelt J, Sundstrom M, Edwards AM, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-152106 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxyisobutyrate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 296 amino acids
Theoretical weight: 31.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31937 (Residues: 41-335; Coverage: 88%)
Gene name: HIBADH
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 50.053Å b: 122.745Å c: 200.397Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.247
Expression system: Escherichia coli

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