› 2gi7

X-ray diffraction
2.4Å resolution

Crystal structure of human platelet Glycoprotein VI (GPVI)

Released:
DOI: 10.2210/pdb2gi7/pdb
PDB entry 2gi7 coloured by chain, front view.
PDB entry 2gi7 coloured by chain, side view.
PDB entry 2gi7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI.
Horii K, Kahn ML, Herr AB
Blood 108 936-42 (2006)
PMID: 16861347

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet glycoprotein VI Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HCN6 (Residues: 21-203; Coverage: 57%)
Gene name: GP6
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 114.057Å b: 45.286Å c: 75.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.276
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Adhesion mechanisms in platelet function.
Ruggeri et al. (2007)
21 more

12 mentions without citation

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
Flierl et al. (2015)
11 more