› 2giv

X-ray diffraction
1.94Å resolution

Human MYST histone acetyltransferase 1

Released:
DOI: 10.2210/pdb2giv/pdb
PDB entry 2giv coloured by chain, front view.
PDB entry 2giv coloured by chain, side view.
PDB entry 2giv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min J, Wu H, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 174-449; Coverage: 60%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
2 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 1 x CL
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 46.305Å b: 58.577Å c: 119.753Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.207 0.262
Expression system: Escherichia coli

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