› 2gk2

X-ray diffraction
2.2Å resolution

Crystal structure of the N terminal domain of human CEACAM1

Released:
DOI: 10.2210/pdb2gk2/pdb
PDB entry 2gk2 coloured by chain, front view.
PDB entry 2gk2 coloured by chain, side view.
PDB entry 2gk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.
Fedarovich A, Tomberg J, Nicholas RA, Davies C
Acta Crystallogr D Biol Crystallogr 62 971-9 (2006)
PMID: 16929097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-146698 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carcinoembryonic antigen-related cell adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13688 (Residues: 32-141; Coverage: 22%)
Gene names: BGP, BGP1, CEACAM1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NI 2 x NI
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P63
Unit cell:
a: 86.2Å b: 86.2Å c: 62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.258
Expression system: Escherichia coli

Quick links

Citations

12 citation in other articles

The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil.
Conners et al. (2008)
11 more

16 mentions without citation

CEACAM1 structure and function in immunity and its therapeutic implications.
Kim et al. (2019)
15 more