› 2gpu

X-ray diffraction
1.7Å resolution

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen

Released:
DOI: 10.2210/pdb2gpu/pdb
PDB entry 2gpu coloured by chain, front view.
PDB entry 2gpu coloured by chain, side view.
PDB entry 2gpu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.
Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT
J Biol Chem 281 37773-81 (2006)
PMID: 16990259

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand OHT 1 x OHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P41212
Unit cell:
a: 64.01Å b: 64.01Å c: 138.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.
Deblois et al. (2013)
15 more

4 mentions without citation

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database.
Wang et al. (2017)
3 more