› 2gpv

X-ray diffraction
2.85Å resolution

Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide

Released:
DOI: 10.2210/pdb2gpv/pdb
PDB entry 2gpv coloured by chain, front view.
PDB entry 2gpv coloured by chain, side view.
PDB entry 2gpv coloured by chain, top view.
Source organisms:
Primary publication:
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.
Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT
J Biol Chem 281 37773-81 (2006)
PMID: 16990259

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158636 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen-related receptor gamma Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 230 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
(spotted green pufferfish) hypothetical protein Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 22 amino acids
Theoretical weight: 2.6 KDa
Source organism: Tetraodon nigroviridis
Expression system: Not provided
UniProt:
  • Canonical: Q4RA23 (Residues: 135-156; Coverage: 13%)
Gene name: GSTENG00037368001

Ligands and Environments

1 bound ligand:
Ligand OHT 6 x OHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 200.22Å b: 117.17Å c: 90.47Å
α: 90° β: 102.36° γ: 90°
R-values:
R R work R free
0.221 0.219 0.279
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

16 review citations

Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.
Deblois et al. (2013)
15 more

5 mentions without citation

Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
Phelan et al. (2010)
4 more