› 2gsf

X-ray diffraction
1.77Å resolution

The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region

Released:
DOI: 10.2210/pdb2gsf/pdb
PDB entry 2gsf coloured by chain, front view.
PDB entry 2gsf coloured by chain, side view.
PDB entry 2gsf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Davis T, Dong A, Newman EM, MacKenzie F, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 41.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P21
Unit cell:
a: 54.163Å b: 38.274Å c: 76.333Å
α: 90° β: 102.39° γ: 90°
R-values:
R R work R free
0.16 0.158 0.195
Expression system: Escherichia coli

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