› 2gtj

Solution NMR

Reduced form of ADAP hSH3-N-domain

Released:
DOI: 10.2210/pdb2gtj/pdb
PDB entry 2gtj coloured by chain, ensemble of 20 models, front view.
PDB entry 2gtj coloured by chain, ensemble of 20 models, side view.
PDB entry 2gtj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Redox-regulated conformational changes in an SH3 domain.
Zimmermann J, Kühne R, Sylvester M, Freund C
Biochemistry 46 6971-7 (2007)
PMID: 17511475

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127296 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FYN-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15117 (Residues: 486-579; Coverage: 12%)
Gene names: FYB, FYB1, SLAP130
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures.
Ye et al. (2013)
1 more

3 mentions without citation

Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
Sylvester et al. (2010)
2 more