› 2gx9

X-ray diffraction
2.1Å resolution

X-ray structure of influenza virus NS1 effector domain

Released:
DOI: 10.2210/pdb2gx9/pdb
PDB entry 2gx9 coloured by chain, front view.
PDB entry 2gx9 coloured by chain, side view.
PDB entry 2gx9 coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
X-ray structure of influenza virus NS1 effector domain.
Bornholdt ZA, Prasad BV
Nat Struct Mol Biol 13 559-60 (2006)
PMID: 16715094

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179851 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.74 KDa
Source organism: unidentified influenza virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6LD08 (Residues: 79-207; Coverage: 56%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)
Structure domains: Influenza virus non-structural protein, effector domain

Ligands and Environments

1 bound ligand:
Ligand SCN 3 x SCN
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4322
Unit cell:
a: 59Å b: 59Å c: 268.022Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.223
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The multifunctional NS1 protein of influenza A viruses.
Hale et al. (2008)
14 more

23 mentions without citation

Structural basis for suppression of a host antiviral response by influenza A virus.
Das et al. (2008)
22 more