› 2gyp

X-ray diffraction
1.4Å resolution

Diabetes mellitus due to a frustrated Schellman motif in HNF-1a

Released:
DOI: 10.2210/pdb2gyp/pdb
PDB entry 2gyp coloured by chain, front view.
PDB entry 2gyp coloured by chain, side view.
PDB entry 2gyp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.
Narayana N, Phillips NB, Hua QX, Jia W, Weiss MA
J Mol Biol 362 414-29 (2006)
PMID: 16930618

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 1-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 33 amino acids
Theoretical weight: 3.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20823 (Residues: 2-32; Coverage: 5%)
Gene names: HNF1A, TCF1

Ligands and Environments

No bound ligands
2 modified residues:
Ligand NLE 2 x NLE
Ligand DAL 2 x DAL

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21212
Unit cell:
a: 29.18Å b: 42.95Å c: 42.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.228 0.288
Expression system: Not provided

Quick links

Citations

5 review citations

Genetically modified pigs for biomedical research.
Luo et al. (2012)
4 more

3 mentions without citation

Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α.
Real Hernandez et al. (2015)
2 more