› 2gyz

X-ray diffraction
1.76Å resolution

Crystal structure of human artemin

Released:
DOI: 10.2210/pdb2gyz/pdb
PDB entry 2gyz coloured by chain, front view.
PDB entry 2gyz coloured by chain, side view.
PDB entry 2gyz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.
Wang X, Baloh RH, Milbrandt J, Garcia KC
Structure 14 1083-92 (2006)
PMID: 16765900

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Artemin Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5T4W7 (Residues: 122-220; Coverage: 55%)
Gene names: ARTN, EVN
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P6522
Unit cell:
a: 47.942Å b: 47.942Å c: 190.059Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.239 0.255
Expression system: Trichoplusia ni

Quick links

Citations

10 review citations

GDNF family receptor complexes are emerging drug targets.
Bespalov et al. (2007)
9 more

7 mentions without citation

Mechanical strength of 17,134 model proteins and cysteine slipknots.
Sikora et al. (2009)
6 more