› 2gzk

Solution NMR

Structure of a complex of tandem HMG boxes and DNA

Released:
DOI: 10.2210/pdb2gzk/pdb
PDB entry 2gzk coloured by chain, front view.
PDB entry 2gzk coloured by chain, side view.
PDB entry 2gzk coloured by chain, top view.
Source organisms:
Primary publication:
Structure of a complex of tandem HMG boxes and DNA.
Stott K, Tang GS, Lee KB, Thomas JO
J Mol Biol 360 90-104 (2006)
PMID: 16813837

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115318 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
High mobility group protein B1; Sex-determining region Y protein Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.99 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q05066 (Residues: 56-130; Coverage: 37%)
  • Canonical: P63159 (Residues: 82-165; Coverage: 39%)
Gene names: Hmg-1, Hmg1, Hmgb1, SRY, TDF
Sequence domains: HMG (high mobility group) box
Structure domains: High mobility group box domain
5'-D(*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*GP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 16 nucleotides
Theoretical weight: 4.93 KDa
5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*C)-3' Chain: C
Molecule details ›
Chain: C
Length: 16 nucleotides
Theoretical weight: 4.86 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

8 review citations

HMGB1 in health and disease.
Kang et al. (2014)
7 more

23 mentions without citation

Absence of a simple code: how transcription factors read the genome.
Slattery et al. (2014)
22 more