› 2gzv

X-ray diffraction
1.12Å resolution

The cystal structure of the PDZ domain of human PICK1

Released:
DOI: 10.2210/pdb2gzv/pdb
PDB entry 2gzv coloured by chain, front view.
PDB entry 2gzv coloured by chain, side view.
PDB entry 2gzv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA
Protein Sci 16 683-94 (2007)
PMID: 17384233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-192552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PRKCA-binding protein Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRD5 (Residues: 18-105; Coverage: 21%)
Gene names: PICK1, PRKCABP
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 79.588Å b: 37.257Å c: 29.442Å
α: 90° β: 95.75° γ: 90°
R-values:
R R work R free
0.15 0.149 0.169
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Engineering of recombinant crystallization chaperones.
Koide S. (2009)
5 more

9 mentions without citation

A specificity map for the PDZ domain family.
Tonikian et al. (2008)
8 more