› 2h2r

X-ray diffraction
1.5Å resolution

Crystal structure of the human CD23 Lectin domain, apo form

Released:
DOI: 10.2210/pdb2h2r/pdb
PDB entry 2h2r coloured by chain, front view.
PDB entry 2h2r coloured by chain, side view.
PDB entry 2h2r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.
Wurzburg BA, Tarchevskaya SS, Jardetzky TS
Structure 14 1049-58 (2006)
PMID: 16765898

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139191 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin epsilon Fc receptor soluble form Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06734 (Residues: 150-321; Coverage: 54%)
Gene names: CD23A, CLEC4J, FCE2, FCER2, IGEBF
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: C2
Unit cell:
a: 112.354Å b: 50.667Å c: 75.061Å
α: 90° β: 127.09° γ: 90°
R-values:
R R work R free
0.126 0.124 0.165
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

IgE in allergy and asthma today.
Gould et al. (2008)
4 more

4 mentions without citation

Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.
Yuan et al. (2013)
3 more