› 2h4e

X-ray diffraction
1.45Å resolution

Crystal structure of Cys10 sulfonated transthyretin

Released:
DOI: 10.2210/pdb2h4e/pdb
PDB entry 2h4e coloured by chain, front view.
PDB entry 2h4e coloured by chain, side view.
PDB entry 2h4e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the protective role of sulfite against transthyretin amyloid formation.
Gales L, Saraiva MJ, Damas AM
Biochim Biophys Acta 1774 59-64 (2007)
PMID: 17175208

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand CSU 2 x CSU

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21212
Unit cell:
a: 42.331Å b: 85.945Å c: 63.404Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.198
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases.
Wieczorek et al. (2021)
2 more

1 mention without citation

Molecular tweezers targeting transthyretin amyloidosis.
Ferreira et al. (2014)