› 2h68

X-ray diffraction
1.79Å resolution

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

Released:
DOI: 10.2210/pdb2h68/pdb
PDB entry 2h68 coloured by chain, front view.
PDB entry 2h68 coloured by chain, side view.
PDB entry 2h68 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL
Nat Struct Mol Biol 13 704-12 (2006)
PMID: 16829959

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 134.591Å b: 46.359Å c: 112.369Å
α: 90° β: 117.15° γ: 90°
R-values:
R R work R free
0.178 0.166 0.192
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Chromatin modifications and their function.
Kouzarides T. (2007)
45 more

3 mentions without citation

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
Ruthenburg et al. (2006)
2 more