› 2h6k

X-ray diffraction
1.89Å resolution

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

Released:
DOI: 10.2210/pdb2h6k/pdb
PDB entry 2h6k coloured by chain, front view.
PDB entry 2h6k coloured by chain, side view.
PDB entry 2h6k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL
Nat Struct Mol Biol 13 704-12 (2006)
PMID: 16829959

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158479 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Histone H3 K4-Me 9-residue peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MLZ 2 x MLZ

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 133.473Å b: 46.521Å c: 112.11Å
α: 90° β: 116.86° γ: 90°
R-values:
R R work R free
0.162 0.146 0.19
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

46 review citations

Chromatin modifications and their function.
Kouzarides T. (2007)
45 more

2 mentions without citation

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
Ruthenburg et al. (2006)
1 more