› 2h77

X-ray diffraction
2.33Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand T3 1 x T3
1 modified residue:
Ligand CAS 4 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 117.569Å b: 80.626Å c: 62.614Å
α: 90° β: 121.09° γ: 90°
R-values:
R R work R free
0.19 0.187 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
12 more

5 mentions without citation

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.
Moran et al. (2017)
4 more