› 2h7t

Solution NMR

Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)

Released:
DOI: 10.2210/pdb2h7t/pdb
PDB entry 2h7t coloured by chain, ensemble of 20 models, front view.
PDB entry 2h7t coloured by chain, ensemble of 20 models, side view.
PDB entry 2h7t coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2).
Kuang Z, Yao S, Keizer DW, Wang CC, Bach LA, Forbes BE, Wallace JC, Norton RS
J Mol Biol 364 690-704 (2006)
PMID: 17020769

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148276 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18065 (Residues: 220-325; Coverage: 37%)
Gene names: BP2, IBP2, IGFBP2
Sequence domains: Thyroglobulin type-1 repeat
Structure domains: Thyroglobulin type-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.
Brown et al. (2009)
5 more

7 mentions without citation

Insulin-like growth factor system in cancer: novel targeted therapies.
Brahmkhatri et al. (2015)
6 more