Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- EGF-like domain
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- EGF-type aspartate/asparagine hydroxylation site
- EGF-like calcium-binding, conserved site
- EGF-like calcium-binding domain
- Serine proteases, trypsin family, serine active site
4 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133212 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Activated factor Xa heavy chain
Molecule details ›
Chain: H
Length: 233 amino acids
Theoretical weight: 26.35 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 233 amino acids
Theoretical weight: 26.35 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00742 (Residues: 235-467; Coverage: 51%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain
Molecule details ›
Chain: L
Length: 149 amino acids
Theoretical weight: 16.37 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Structure domains: Laminin
Length: 149 amino acids
Theoretical weight: 16.37 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00742 (Residues: 86-234; Coverage: 33%)
Sequence domains:
Structure domains: Laminin
TIL domain-containing protein
Molecule details ›
Chain: C
Length: 84 amino acids
Theoretical weight: 9.66 KDa
Source organism: Ancylostoma caninum
Expression system: Escherichia coli
UniProt:
Structure domains: Laminin
Length: 84 amino acids
Theoretical weight: 9.66 KDa
Source organism: Ancylostoma caninum
Expression system: Escherichia coli
UniProt:
- Canonical: Q16938 (Residues: 8-91; Coverage: 92%)
Structure domains: Laminin
