› 2hac

Solution NMR

Structure of Zeta-Zeta Transmembrane Dimer

Released:
DOI: 10.2210/pdb2hac/pdb
PDB entry 2hac coloured by chain, ensemble of 15 models, front view.
PDB entry 2hac coloured by chain, ensemble of 15 models, side view.
PDB entry 2hac coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.
Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW
Cell 127 355-68 (2006)
PMID: 17055436

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149100 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD3 zeta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 33 amino acids
Theoretical weight: 3.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20963 (Residues: 28-60; Coverage: 23%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains: T-cell surface glycoprotein CD3 zeta chain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Mechanisms for T cell receptor triggering.
van der Merwe et al. (2011)
27 more

27 mentions without citation

Influences of membrane mimetic environments on membrane protein structures.
Zhou et al. (2013)
26 more