› 2hde

Solution NMR

Solution Structure of Human SAP18

Released:
DOI: 10.2210/pdb2hde/pdb
PDB entry 2hde coloured by chain, ensemble of 20 models, front view.
PDB entry 2hde coloured by chain, ensemble of 20 models, side view.
PDB entry 2hde coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.
McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ
Biochemistry 45 11974-82 (2006)
PMID: 17002296

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone deacetylase complex subunit SAP18 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00422 (Residues: 6-149; Coverage: 94%)
Gene names: GIG38, SAP18
Sequence domains: Sin3 associated polypeptide p18 (SAP18)
Structure domains: ASAP complex, SAP18 subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Restrained molecular dynamics (Torsion angle and Cartesian dynamics)
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Basic concepts of epigenetics: impact of environmental signals on gene expression.
Mazzio et al. (2012)
2 more

4 mentions without citation

The natural history of ubiquitin and ubiquitin-related domains.
Burroughs et al. (2012)
3 more