› 2hdm

Solution NMR

Solution structure of V21C/V59C Lymphotactin/XCL1

Released:
DOI: 10.2210/pdb2hdm/pdb
PDB entry 2hdm coloured by chain, ensemble of 20 models, front view.
PDB entry 2hdm coloured by chain, ensemble of 20 models, side view.
PDB entry 2hdm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity.
Tuinstra RL, Peterson FC, Elgin ES, Pelzek AJ, Volkman BF
Biochemistry 46 2564-73 (2007)
PMID: 17302442

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lymphotactin Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P47992 (Residues: 23-114; Coverage: 99%)
Gene names: LTN, SCYC1, XCL1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT.
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Proteins that switch folds.
Bryan et al. (2010)
5 more

10 mentions without citation

Protein metamorphosis: the two-state behavior of Mad2.
Luo et al. (2008)
9 more