› 2hky

Solution NMR

NMR solution structure of human RNase 7

Released:
DOI: 10.2210/pdb2hky/pdb
PDB entry 2hky coloured by chain, ensemble of 15 models, front view.
PDB entry 2hky coloured by chain, ensemble of 15 models, side view.
PDB entry 2hky coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.
Huang YC, Lin YM, Chang TW, Wu SJ, Lee YS, Chang MD, Chen C, Wu SH, Liao YD
J Biol Chem 282 4626-4633 (2007)
PMID: 17150966

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease 7 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H1E1 (Residues: 29-156; Coverage: 100%)
Gene names: RNASE7, UNQ2516/PRO6006
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

24 review citations

Microbial symbiosis with the innate immune defense system of the skin.
Gallo et al. (2011)
23 more

13 mentions without citation

The role of human ribonuclease A family in health and diseases: A systematic review.
Sun et al. (2022)
12 more